Probing the regional distribution of pulmonary gas exchange through single-breath gas- and dissolved-phase Xe MR imaging
نویسندگان
چکیده
S. Sivaram Kaushik, Matthew S. Freeman, Zackary I. Cleveland, John Davies, Jane Stiles, Rohan S. Virgincar, Scott H. Robertson, Mu He, Kevin T. Kelly, W. Michael Foster, H. Page McAdams, and Bastiaan Driehuys Department of Biomedical Engineering, Duke University, Durham, North Carolina; Center for In Vivo Microscopy, Duke University Medical Center, Durham, North Carolina; Graduate Program in Medical Physics, Duke University, Durham, North Carolina; Department of Pulmonary, Allergy, and Critical Care Medicine, Duke University Medical Center, Durham, North Carolina; Department of Electrical and Computer Engineering, Duke University, Durham, North Carolina; Department of Radiation Oncology, Duke University Medical Center, Durham, North Carolina; and Department of Radiology, Duke University Medical Center, Durham, North Carolina
منابع مشابه
Hyperpolarized 129Xe MR Imaging of Alveolar Gas Uptake in Humans
BACKGROUND One of the central physiological functions of the lungs is to transfer inhaled gases from the alveoli to pulmonary capillary blood. However, current measures of alveolar gas uptake provide only global information and thus lack the sensitivity and specificity needed to account for regional variations in gas exchange. METHODS AND PRINCIPAL FINDINGS Here we exploit the solubility, hig...
متن کاملProbing the regional distribution of pulmonary gas exchange through single-breath gas- and dissolved-phase 129Xe MR imaging.
Although some central aspects of pulmonary function (ventilation and perfusion) are known to be heterogeneous, the distribution of diffusive gas exchange remains poorly characterized. A solution is offered by hyperpolarized 129Xe magnetic resonance (MR) imaging, because this gas can be separately detected in the lung's air spaces and dissolved in its tissues. Early dissolved-phase 129Xe images ...
متن کاملIn Vivo MR Imaging of Pulmonary Perfusion and Gas Exchange in Rats via Continuous Extracorporeal Infusion of Hyperpolarized 129Xe
BACKGROUND Hyperpolarized (HP) (129)Xe magnetic resonance imaging (MRI) permits high resolution, regional visualization of pulmonary ventilation. Additionally, its reasonably high solubility (>10%) and large chemical shift range (>200 ppm) in tissues allow HP (129)Xe to serve as a regional probe of pulmonary perfusion and gas transport, when introduced directly into the vasculature. In earlier ...
متن کاملDissolved Phase MR Imaging of Continuously Infused Hyperpolarized Xe Using Hydrophobic Gas Exchange Membranes
Introduction: Hyperpolarized (HP) noble gases enable a wide range of novel MR applications including non-invasive, regional visualization of pulmonary function [1]. HP Xe is of particular interest because it is soluble in tissues and its large (~300 ppm) chemical shift range provides detailed information about the local chemical environment including physiologically important parameters such as...
متن کاملSimultaneous Imaging of Ventilation Distribution and Gas Exchange in the Human Lung using Hyperpolarized Xe129 MRI
Introduction: The high solubility of xenon in biological tissues, combined with an exquisite sensitivity to its environment that results in an enormous range of chemical shifts upon solution, make hyperpolarized Xe129 particularly attractive for exploring characteristics of lung function, such as gas exchange, that are not accessible by using hyperpolarized He3. With improvements in gas-polariz...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2013